Example directory layout for the virtual host example.com

/example.com
  conf/
    httpd.conf
    django_project_name/
  htdocs/
  local_apps/
  logs/
  uploads/
  templates/

conf/

Configuration files live in this directory, in addition to the django_project that contains the manage.py, settings.py, and urls.py files.

htdocs/

This will be the root of your MEDIA_URL likely this would be the document root of most sites.

local_apps/

Custom apps written for this project aka Quick Junk apps that haven't been made multi-site aware.

logs/

Either the site logs or a link to the directory that contains the site logs.

uploads/

Files uploaded by applications.

templates/

This area is used to override templates from your reusable apps.